MUTANT p53 CONTROLS
THE TUMOR MICROENVIRONMENT
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOF) distinct from the tumor suppressor of the wild-type p53. We found that specific mutp53 GOF proteins are capable of releasing a unique subset of exosomes leading to the reprogramming tumor-associated macrophages converting them to tumor supportive immune population in models of colon cancer and in patients.
OUTER-MEMBRANE -VESICLES (OMVS) IN HOST-PATHOGEN INTERACTIONS LEADING TO CANCER
We attempt to define the role of OMVs in driving inflammation-associated lung tumorigenesis in the presence of mutant p53. To that end, we determine the short RNAs (sRNAs) composition of OMVs shed by pathogenic bacteria invading the lung tissue and the specific transcriptional response of mutant p53 lung carcinoma cells to OMVs. We elucidate the modes of communications between invading bacteria and cancer cells and the effect of bacterial extracellular vesicles on the malignant process.
The DaRT technology is a unique form of brachytherapy based on short-lived atoms releasing alpha particles. We explore ways decipher molecular mechanisms fundamental for the spectrum of resistance to sensitivity of cancer cells to the treatment.